Pengaruh Perlindungan Propolis Terhadap Gambaran Histopatologi Ginjal Tikus Putih (Rattus Norvegicus) Jantan Galur Wistar Yang Diinduksi Ibuprofen

Abstract

The use of ibuprofen in high doses and for a long period of time risks causing kidney damage. Propolis contains active compounds such as flavonoids, phenolics, and phenolic acids which have antioxidant and anti-inflammatory properties. This study aims to determine the effect of propolis protection on the histopathological picture of the kidneys of male white rats (Rattus norvegicus) of the Wistar strain induced by ibuprofen. The research method applied is True Experimental with a Post-Test Only Control Group Design. 30 samples of male Wistar rats were divided into 5 treatment groups. the normal group (N) did not receive treatment, the negative control group (K-) received ibuprofen at a dose of 400 mg/kgBW, treatment group 1 (P1), treatment group 2 (P2), and treatment group 3 (P3) received ibuprofen at a dose of 400 mg/kgBW then propolis was added at a dose of 0.13 ml (P1), 0.26 (P2) ml, 0.52 ml (P3). This study was conducted for 14 days. The results of the Kruskal-Wallis test showed differences in the level of histopathological damage to the kidneys in white rats between groups (p<0.001). The Mann-Whitney post hoc test showed significant differences between the normal group and all treatment groups, as well as between the negative control group and treatment groups 2 and 3. There was no significant difference between the negative control group and treatment group 1. The conclusion of this study is that there is an effect of propolis administration on the histopathological picture of the kidneys of male white rats (Rattus norvegicus) of the Wistar strain induced by ibuprofen.